A manuscript written in Egypt in 1200 B.C. provides suggestions for overcoming baldness. More than 3000 years have passed and still hope springs eternal in the brain of the bald-headed man.

FDA approved baldness drug destroy sperm, cause infertility and ejaculation disorders, and a serious form of prostate cancer even after stop using. (Source Health Canada http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/_2012/2012_38-eng.php )

Despite claims to the contrary, there are no treatments or remedies can prevent or correct baldness throughout the world except our Health Canada approved EN product Stemcelex.

The Hedgehog Gene (hh) was first identified in the classic Heidelberg screens of Eric Wieschaus and Christiane Nusslein-Volhard as published in 1978. These screens, which led to their winning the Nobel Prize in 1995 along with developmental geneticist Edward B.Lewis.

Hedgehog-Gli signaling pathway operates and controls Stem cell and progenitor proliferation, survival and behavior. This pathway is one of the key models of communication that control Stem cell and derived progenitors in multiple systems. In the skin Shh is required for hair follicle morphogenesis during embryogenesis and for regulating follicular growth and cycling in the adult. Abnormal activation of the Hh pathway has been demonstrated in variety of human tumors such as basal cell carcinomas, and play important role in male and female pattern baldness.

Recent studies indicate that synthetic small molecule agonists topically applied to modulate follicular cycling in adult mouse skin. The Hh-agonist stimulated the transition from resting (telogen) to the growth (anagen) of the hair cycle in adult mouse skin suggested that topical application of Hh-agonist could be effective in treating conditions of decreased proliferation and aberrant follicular cycling in the scalp including androgenetic alopecia.(Paladini et al). But several Shh inhibitors have not succeeded in the clinic for hair growth, except clinical trials in BCC and pancreatic cancer.

Pharmacognosist and inventor Mohammed Alal Khan succeeded to isolated small molecule from plant ingredients (steroidal alkaloids) antagonist to modulated sonic hedgehog signaling pathway and stimulated hair follicle stem cell to re-grow hair on bald scalp which led to him winning World Anti Drug Day Award in the year 1992 and Gold Medal in the year 1993.